Peer-reviewed veterinary case report
PCR finds Leishmania but not Mycobacterium in dog skin granulomas
By Cornegliani, L et al.·Published in Veterinary dermatology·2005·Ambulatorio Veterinario Associato, Italy·View original on PubMed →
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Original publication title: PCR technique detection of Leishmania spp. but not Mycobacterium spp. in canine cutaneous 'sterile' pyogranuloma/granuloma syndrome.
- Species:
- dog
Plain-English summary
A group of dogs with a skin condition called cutaneous 'sterile' pyogranuloma/granuloma syndrome (SPGS) had skin samples tested for Leishmania and Mycobacterium infections. The tests showed that 21 out of 46 samples were positive for Leishmania, while none showed Mycobacterium. This suggests that Leishmania could be a factor in this skin disorder, and it’s important for vets to check for it when diagnosing SPGS. Treatment options may vary, but identifying the underlying cause is crucial for effective management.
People also search for: dog skin problems Leishmania · cutaneous granuloma treatment dog · dog pyogranuloma syndrome symptoms
Abstract
Cutaneous 'sterile' pyogranuloma/granuloma syndrome (SPGS) is an uncommon canine skin disorder of unknown aetiopathogenesis. Histopathological findings and failure to demonstrate an aetiologic agent are suggestive of this syndrome. Nevertheless, it has been hypothesized that SPGS may be related to an immune response against persistent endogenous or exogenous antigens. The presence of Leishmania and Mycobacterium organisms was investigated by polymerase chain reaction (PCR) techniques in 46 canine skin samples histopathologically diagnosed as SPGS. Concomitantly, an immunohistochemical technique for Leishmania detection was applied on the same samples and the results were compared with those from PCR. The PCR technique yielded positive results for Leishmania spp. in 21 out of 46 skin samples. The results of immunohistochemical techniques were identical to those obtained by PCR. The PCR technique gave negative results for Mycobacterium spp. in all the samples examined. These results suggest the importance of looking for Leishmania spp. in skin biopsies with histopathological findings consistent with the diagnosis of SPGS.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/16101794/