Peer-reviewed veterinary case report
How PD-1 affects immune response in dogs with leishmaniasis
By Rebech, Gabriela Torres et al.·Published in Veterinary immunology and immunopathology·2020·o Paulo State University (UNESP), Brazil·View original on PubMed →
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Original publication title: PD-1 regulates leishmanicidal activity and IL-17 in dogs with leishmaniasis.
- Species:
- dog
Plain-English summary
A group of dogs with leishmaniasis, a disease caused by a parasite, showed signs of weakened immune responses. Researchers tested a treatment using PD-1 blocking antibodies, which helped boost the dogs' immune activity against the parasites. The treatment increased certain immune markers and reduced the number of parasites in the dogs' spleen cells. While this study was done in the lab, it suggests that blocking PD-1 could be a promising way to help dogs fight leishmaniasis more effectively in the future.
People also search for: dog leishmaniasis treatment · PD-1 antibodies for dogs · boosting dog immune system leishmaniasis
Abstract
Leishmaniasis is an immunosuppressive disease caused by protozoa of the genus Leishmania, for which dogs are the domestic reservoir. The programmed cell death-1 molecule (PD-1) is highly expressed in leukocyte cells of dogs with leishmaniasis, and it promotes T lymphocyte exhaustion and suppression of cytokine secretion. Because PD-1 has a suppressive function regarding cell immunity, we evaluated the effect of PD-1 blocking antibodies on NO, ROS and interleukin 17 (IL-17) production and on parasite load in spleen leukocyte cultures from dogs with leishmaniasis. In vitro, PD-1 blocking promoted increased levels of intracellular NO and NOand reduced the levels of IL-17 in the culture supernatant, in addition to reducing the parasite load, but it did not change ROS levels. We conclude that PD-1 participates in the regulation of the immune response and that the blocking antibody is effective in restoring host microbicidal activity. This can be investigated in an immunotherapeutic study in the future.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/31733502/