Peer-reviewed veterinary case report
Cat lymphoma with intestinal wall perforation and vomiting
By Kariya, K et al.·Published in Veterinary pathology·1997·Department of Biomedical Sciences, Japan·View original on PubMed →
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Original publication title: Perforin-like immunoreactivity in four cases of lymphoma of large granular lymphocytes in the cat.
- Species:
- cat
Plain-English summary
Four cats with severe gastrointestinal issues, including not eating, vomiting, and diarrhea, were diagnosed with a type of cancer called large granular lymphoma. During surgery and post-mortem examinations, vets found thickened and damaged intestines, swollen lymph nodes, and enlarged spleens. The cancer cells were identified as coming from a specific type of immune cell, which could help in diagnosing this condition in other cats. Unfortunately, the prognosis for these cats was poor due to the advanced nature of the disease.
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Abstract
Tumors composed of discrete round cells with large eosinophilic granules in their cytoplasm were observed in four cats. These cats were presented with severe gastrointestinal signs, including anorexia, vomiting, and diarrhea. The exploratory laparotomy in two cats and necropsy in the other two revealed thickening and perforation of the intestinal walls, enlargement of the mesenteric, ileocolic, and/or colic lymph nodes, and splenomegaly. Histologically, there was severe and disseminated infiltration of the tumor cells in the affected organs. In the two cats necropsied, the spleen and the jejunal mucosa appeared to be the primary organs involved. The tumor cells of all the cats showed the pore-forming protein (perforin)-like immunoreactivity unique to the cytotoxic lymphocytes but failed to show histamine immunoreactivity. These results indicate that the tumor cells were derived from large granular lymphocytes and that perforinlike immunoreactivity may be a useful marker for histologic diagnosis of feline large granular lymphoma.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/9066084/