Peer-reviewed veterinary case report
Accuracy of Alere test for diagnosing canine visceral leishmaniasis
By Souza Filho, Job Alves de et al.·Published in Veterinary parasitology·2016·Brazilian National Reference Laboratory for Diagnosis of Visceral Leishmaniasis, Brazil·View original on PubMed →
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Original publication title: Performance of Alere™ immunochromathographic test for the diagnosis of canine visceral leishmaniasis.
- Species:
- dog
Plain-English summary
A group of dogs in Brazil were tested for canine visceral leishmaniasis, a serious disease that can affect both dogs and humans. Researchers used a new test called the Alere™ immunochromatographic test to see how well it could detect the disease compared to other established methods. The Alere™ test showed a high sensitivity, meaning it correctly identified most dogs with the disease, and it had perfect specificity, meaning it didn't falsely identify healthy dogs as sick. This test could be a useful tool for diagnosing this disease in dogs.
People also search for: dog leishmaniasis symptoms · canine leishmaniasis test · how to treat leishmaniasis in dogs
Abstract
The diagnosis and control of canine visceral leishmaniasis (CVL) has fundamental importance in the control of human visceral leishmaniasis. In this context, the immunochromathographic test (ICT) has emerged as a valuable diagnostic tool. Currently, in Brazil, the algorithm for the diagnosis of CVL uses Dual Path Platform (DPP) ICT as a screening test and ELISA as a confirmatory test. However, the DPP(®) ICT has been facing a problem of insufficient production to meet the national demand. Here, the Alere™ canine visceral leishmaniasis ICT was tested with serum samples from 159 dogs, including symptomatic, asymptomatic and healthy dogs, characterized by DPP(®) ICT and ELISA (panel A), or ELISA and Indirect Immunofluorescence Assay (IFA) (panel B), and parasitological examination as gold standard. In this study, the Alere™ ICT obtained 0.974 sensitivity for panel A and 0.854 sensitivity for panel B. The specificity was 1.0 for both panels. Thus, the Alere™ ICT has potential to be used for the serological diagnosis of CVL.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/27369585/