Peer-reviewed veterinary case report
Peri-articular histiocytic sarcoma linked to joint disease in Bernese
By van Kuijk, L et al.·Published in Journal of veterinary internal medicine·2013·De Ottenhorst, Netherlands·View original on PubMed →
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Original publication title: Peri-articular histiocytic sarcoma and previous joint disease in Bernese Mountain Dogs.
- Species:
- dog
Plain-English summary
A Bernese Mountain Dog with a history of joint problems may be at a higher risk for developing a type of cancer called peri-articular histiocytic sarcoma (PAHS) in the same joint. In a study of 920 Bernese Mountain Dogs, it was found that those with previous joint disease were significantly more likely to develop PAHS compared to those without joint issues. Specifically, the left and right elbows, shoulders, stifles, and carpal joints were noted as common sites for this cancer to occur. Pet owners should keep an eye out for any unusual swelling around their dog's joints, especially if there has been prior joint disease.
People also search for: Bernese Mountain Dog joint problems · dog cancer symptoms · peri-articular swelling in dogs · PAHS in dogs · joint disease in Bernese Mountain Dogs
Abstract
BACKGROUND: Peri-articular histiocytic sarcoma (PAHS) occurs in dogs, including Bernese Mountain Dogs (BMD). An etiologic relationship with previous joint disease has not been documented. HYPOTHESIS: Peri-articular histiocytic sarcoma in BMD will be more frequently encountered around previously diseased joints compared with normal joints. ANIMALS: 920 European BMD. METHODS: A retrospective study, in which data were obtained through an Internet questionnaire and from 2 veterinary pathology laboratories. Archived samples of hematoxylin-eosin (H&E) staining diagnosed PAHS and synovial cell sarcoma (SCS) were immunolabeled with CD18 and pancytokeratin. Descriptive, comparative, and actuarial statistics comprise the data analysis. RESULTS: All primary synovial tumors were identified as PAHS based on their morphology, positive CD18, and negative pancytokeratin labeling. Joint disease was diagnosed in 226 BMD, of which 15 developed PAHS in a previously diseased joint and 3 in a nondiseased joint. Of the remaining 694 BMD without joint disease, 9 developed PAHS. The odds ratio for a dog with previous joint disease developing PAHS is calculated as 5.4 (95% CI: 2.3-12.5; P < .0001) compared with no previous joint problem. A significant association between previous joint disease and PAHS in the same joint was demonstrated for the left elbow (P = .016), right elbow (P = .006), right shoulder (P = .047), left and right stifle (P < .001), and left carpal joint (P = .010). CONCLUSIONS AND CLINICAL IMPORTANCE: The results of this study suggest a relation between previous joint disease and the development of PAHS in the same joint of European BMD. Owners of BMD should monitor dogs for peri-articular swellings, particularly around previously diseased joints.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/23458888/