Peer-reviewed veterinary case report
Young Labrador with nerve tumor causing seizures and muscle loss
By Suzuki, Mari et al.·Published in The Journal of veterinary medical science·2003·Department of Veterinary Pathology, Japan·View original on PubMed →
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Original publication title: Peripheral neuroblastoma in a young labrador retriever.
- Species:
- dog
Plain-English summary
A 2-year-old Labrador Retriever experienced muscle wasting on one side of its face and then started having seizures. Sadly, the dog passed away two months after these symptoms began. A postmortem exam revealed tumors in the dog's throat and brain, which were identified as peripheral neuroblastoma, a type of cancer that likely started in the nervous system. Unfortunately, there was no successful treatment reported in this case, and the dog did not recover.
People also search for: dog seizures · Labrador Retriever muscle wasting · peripheral neuroblastoma in dogs · dog cancer treatment options
Abstract
A 2-year-old Labrador Retriever developed atrophy of the right temporal muscle, subsequently showed generalized seizure and died 2 months after the clinical onset. Postmortem examination revealed the tumor masses in the right mandibulopharyngeal area, nasopharynx and intracranial space. Histopathologically, these tumor masses were composed of small round neoplastic cells and neuropil-like stroma separated by fibrovascular septa. In the neoplastic masses, small neoplastic cells with round to oval hyperchromatic nuclei and scanty cytoplasm predominated, and angulated neoplastic cells with larger nuclei and moderate cytoplasm were scattered. Immunohistochemically, neoplastic cells were positive for neuron specific enorase, neurofilament protein, chromogranin A, synaptophysin and tyrosine hydroxylase. Based on these findings, this case was diagnosed as peripheral neuroblastoma, presumably originated from the sympathetic ganglion, maybe right craninal cervical ganglion.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/12655127/