Peer-reviewed veterinary case report
Peripheral primitive neuroectodermal tumor in a two-year-old paint horse.
- Journal:
- Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
- Year:
- 2012
- Authors:
- Facemire, Paul R et al.
- Affiliation:
- Department of Veterinary Pathology · United States
- Species:
- horse
Plain-English summary
A 2-year-old male paint horse was brought in because he was very tired and had stopped eating. During the examination, the vet found fluid in his chest and abdomen, along with several lumps in his scrotum. Despite a week of supportive care, the horse developed serious trouble breathing, and the owners decided to euthanize him due to the poor outlook. An examination after death revealed multiple tumors in his scrotum and abdomen, which had spread to several organs. The diagnosis was a rare type of tumor called a peripheral primitive neuroectodermal tumor. Unfortunately, the treatment did not work, leading to the decision for euthanasia.
Abstract
A 2-year-old gelding presented with a history of lethargy and anorexia. Physical examination revealed pleural and abdominal fluid, as well as several masses in the scrotum. The horse became acutely dyspneic despite 7 days of supportive care. Because of the poor prognosis, the owners elected euthanasia. Gross necropsy findings included multiple masses in the scrotum and inguinal canals and along the dorsal peritoneal cavity. The neoplasm infiltrated the kidneys, liver, spleen, mesenteric lymph nodes, mesentery, and abdominal surface of the diaphragm. Histologically, the neoplasm is composed of spindle to round cells arranged in densely cellular areas, vague streams, and rare rosettes. Neoplastic cells were immunoreactive for S-100 protein, glial fibrillary acidic protein, neuron-specific enolase, neurofilament protein, and synaptophysin. Based on gross, histological, and immunohistochemical findings, a diagnosis of peripheral primitive neuroectodermal tumor was made. Primitive neuroectodermal tumors are rarely described in horses that were associated with the eyes.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/22621943/