Peer-reviewed veterinary case report
Cat with persistent nonregenerative anemia and weight loss
By Long, Mackenzie E et al.·Published in Veterinary clinical pathology·2020·Department of Veterinary Biosciences, United States·View original on PubMed →
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Original publication title: Persistent nonregenerative anemia in a 4-year-old cat.
- Species:
- cat
Plain-English summary
A 4-year-old male neutered domestic shorthair cat was brought to the vet after losing a lot of weight and feeling very tired for two months. Tests showed he had severe anemia and kidney problems, which were likely linked to chronic kidney disease. Despite receiving multiple blood transfusions and supportive care, the cat unfortunately passed away. An autopsy revealed serious issues with his bone marrow and kidneys, suggesting that these conditions contributed to his anemia and overall decline.
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Abstract
A 4-year-old male neutered domestic shorthair cat was presented to The Ohio State University College of Veterinary Medicine for a 2-month history of severe weight loss, lethargy, anemia, and bilaterally hyperechoic kidneys with loss of corticomedullary distinction as reported by the referring veterinarian. Relevant initial laboratory results included severe non-regenerative normocytic hypochromic anemia, increased blood urea nitrogen, minimally concentrated urine, proteinuria, and an increased urine protein:creatinine ratio. Cytologic evaluation of a bone marrow aspirate revealed a markedly hypocellular marrow with abundant mucinous material. Gelatinous marrow transformation (GMT) was confirmed histologically by the presence of mucinous material in the bone marrow that stained positive for Alcian blue but negative for periodic acid-Schiff. The cat died despite repeated blood transfusions and supportive care. Gelatinous marrow transformation, immune complex-mediated membranoproliferative glomerulonephritis, and gastrointestinal hemorrhage were observed on autopsy and histology. It is likely that the development of GMT was secondary to chronic kidney disease (CKD) and that CKD, GMT, and gastrointestinal hemorrhage contributed to the cat's non-regenerative anemia.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/32201969/