Peer-reviewed veterinary case report
Ifosfamide chemotherapy dosing and effects in cats with sarcomas
By Rassnick, Kenneth M et al.·Published in American journal of veterinary research·2006·Department of Clinical Sciences, United States·View original on PubMed →
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Original publication title: Phase I trial and pharmacokinetic analysis of ifosfamide in cats with sarcomas.
- Species:
- cat
Plain-English summary
A group of 38 cats with tumors called sarcomas received a chemotherapy drug called ifosfamide to see how well it worked and what side effects it caused. The highest safe dose found was 1,000 mg/m2, and while some cats experienced mild nausea and a drop in white blood cells (neutropenia), there were no serious kidney issues. About 6 out of 27 cats showed some signs of improvement in their tumors. The recommended dose for future treatments is 900 mg/m2 every three weeks.
People also search for: cat sarcoma treatment · ifosfamide for cats · cat chemotherapy side effects
Abstract
OBJECTIVE: To determine the maximally tolerated dose (MTD) and dose-limiting toxicosis (DLT) of ifosfamide in tumor-bearing cats. ANIMALS: 38 cats with resected, recurrent, or metastatic sarcomas. PROCEDURE: The starting dosage of ifosfamide was 400 mg/m(2) of body surface area, IV, and dosages were increased by 50 to 100 mg/m(2) in cohorts of 3 cats. To protect against urotoxicosis, mesna was administered at a dosage equal to 20% of the calculated ifosfamide dosage. Diuresis with saline (0.9% NaCl) solution before and after administration of ifosfamide was used to minimize nephrotoxicosis. Samples for pharmacokinetic analysis were obtained after the MTD was reached. RESULTS: 38 cats were entered into this phase I study and were administered a single dose of ifosfamide at various dosages. The MTD was 1,000 mg/m(2), and neutropenia was the DLT. Seven of 8 episodes of neutropenia were on day 7 after treatment, and 1 cat developed severe neutropenia on day 5. Adverse effects on the gastrointestinal tract were generally mild and self-limiting, the most common of which was nausea during ifosfamide infusion. One cat had signs consistent with a drug-induced hypersensitivity reaction. There were no episodes of hemorrhagic cystitis or nephrotoxicosis. Correlations between pharmacokinetic variables and ifosfamide-associated toxicoses were not found. Preliminary evidence of antitumor activity was observed in 6 of 27 cats with measurable tumors. CONCLUSIONS AND CLINICAL RELEVANCE: The dosage of ifosfamide recommended to treat tumor-bearing cats is 900 mg/m(2) every 3 weeks. This dosage should be used in phase II clinical trials.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/16506919/