Peer-reviewed veterinary case report
Hydroxyurea treatment results for mast cell tumors in dogs
By Rassnick, K M et al.·Published in Veterinary and comparative oncology·2010·Department of Clinical Sciences, United States·View original on PubMed →
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Original publication title: Phase II open-label study of single-agent hydroxyurea for treatment of mast cell tumours in dogs.
- Species:
- dog
Plain-English summary
A group of dogs with mast cell tumors, a type of skin cancer, were treated with a medication called hydroxyurea to see how well it worked. Out of 46 dogs, about 28% showed improvement, with two dogs experiencing complete remission for over 400 days. However, some dogs faced side effects like low blood cell counts, which can lead to anemia. Despite these issues, hydroxyurea proved to be effective for some dogs with this type of cancer, making it a potential treatment option.
People also search for: dog mast cell tumor treatment · hydroxyurea for dogs · mast cell tumor symptoms in dogs
Abstract
This prospective study evaluated the efficacy and safety of hydroxyurea (HU) in dogs with measurable mast cell tumours (MCTs). Dogs were treated with HU at 60 mg kg(-1)per os q24h for 14 days then 30 mg kg(-1) q24h thereafter or until MCT recurrence. Forty-six dogs were enrolled. The overall response rate was 28%. Two dogs had a complete response (CR) for 256 and 448 days, respectively. Eleven dogs had a partial response for a median duration of 46 days (range, 28-189 days). Grade 2 to 4 neutropenia occurred in eight dogs and grade 4 thrombocytopenia in two. Grade 3-4 anaemia occurred in seven dogs; overall, there was a significant decrease in haematocrit after treatment with HU. The median drop in haematocrit was 10%. This study demonstrated that HU has activity in the treatment of MCTs with mild anaemia being the primary adverse event.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/20579323/