Peer-reviewed veterinary case report
Nail loss in two dogs from long-term hydroxyurea cancer treatment
By Marconato, L et al.·Published in The Journal of small animal practice·2007·Clinica Veterinaria L'Arca, Italy·View original on PubMed →
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Original publication title: Unusual dermatological toxicity of hydroxyurea in two dogs with spontaneously occurring tumours.
- Species:
- dog
Plain-English summary
Two dogs receiving long-term treatment with hydroxyurea, a medication often used for certain tumors, developed unusual nail problems, specifically losing several claws on their feet. One dog needed to stop the medication entirely, while the other had a reduced dose to help heal the nail issues. This situation highlights the importance of monitoring for skin-related side effects when using hydroxyurea in dogs. Both dogs showed improvement after adjusting their treatment.
People also search for: dog nail problems hydroxyurea · dog losing claws treatment · side effects of hydroxyurea in dogs
Abstract
Hydroxyurea is a chemotherapeutic agent used to treat hypereosinophilic syndrome, mast cell tumours and many myeloproliferative disorders. It is usually well tolerated; however, reported side effects include myelosuppression and gastrointestinal complications as well as cutaneous toxicity, in very rare cases. We report the unusual appearance of onychomadesis involving several claws on all feet in two canine patients receiving long-term hydroxyurea treatment. The healing of nail lesions required cessation of treatment in one dog and dose reduction in the second animal, supporting a strict relationship between onychopathy and administration of hydroxyurea. The aim of this case report is to increase clinical awareness of dermatological toxicity associated with long-term administration of hydroxyurea.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/17617162/