Peer-reviewed veterinary case report
Photodynamic therapy for the treatment of intranasal tumors in 3 dogs and 1 cat.
- Journal:
- Journal of veterinary internal medicine
- Year:
- 2003
- Authors:
- Lucroy, Michael D et al.
- Affiliation:
- Department of Veterinary Clinical Sciences · United States
Plain-English summary
In this study, three dogs and one cat with tumors inside their noses were treated using a special light therapy called photodynamic therapy (PDT). The treatment was generally well tolerated, and none of the pets experienced any serious side effects from the medication used. After each treatment, all the animals had some facial swelling, but this went away on its own within three days. Following the therapy, the pets showed less severe nosebleeds, sneezing, and nasal discharge. While the improvements lasted for different lengths of time, two of the animals had long-term results similar to those seen with radiation therapy. Overall, this suggests that PDT could be a useful option for treating intranasal tumors in pets, but more research is needed to understand its full potential.
Abstract
Three dogs and 1 cat with intranasal tumors were treated with pyropheophorbide-a-hexyl ether-based photodynamic therapy (PDT). PDT was well tolerated by all the animals, and no adverse effects from photosensitizer injection, such as cutaneous photosensitization, were observed. Facial swelling was observed in all animals after each PDT treatment but resolved spontaneously within 72 hours after treatment. All animals had a decrease in severity of epistaxis, frequency of sneezing, and amount of nasal discharge after PDT. Clinical signs were controlled for variable time, although long-term responses were comparable with radiation therapy in 2 animals. This small case series demonstrates another application for PDT in veterinary medicine. On the basis of these findings. further studies are warranted to define the role of PDT in the management of intranasal tumors in dogs and cats.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/14529144/