Peer-reviewed veterinary case report
Black skin plaques in pugs linked to papillomavirus DNA study
By Narama, I et al.·Published in Journal of comparative pathology·2005·Research Institute of Drug Safety, Japan·View original on PubMed →
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Original publication title: Pigmented cutaneous papillomatosis (pigmented epidermal nevus) in three pug dogs; histopathology, electron microscopy and analysis of viral DNA by the polymerase chain reaction.
- Species:
- dog
Plain-English summary
Three pug dogs were diagnosed with a skin condition called pigmented cutaneous papillomatosis, which caused multiple black plaques on their skin. Tests showed that the skin lesions were associated with a type of virus known as bovine papillomavirus, although no significant viral structures were found in the skin samples. The affected dogs did not show any severe symptoms, and the condition is generally considered benign. Treatment options were not detailed, but monitoring the skin lesions is often recommended for similar cases.
People also search for: pug dog skin problems · black spots on dog skin · pigmented skin lesions in dogs
Abstract
Canine pigmented epidermal nevus (CPEN) is a skin disorder of some breeds of dog characterized by multiple black plaques of the haired and non-haired skin. Three cases of pigmented cutaneous papillomatosis (previously described also as CPEN) in pug dogs were investigated histopathologically, immunohistochemically and electron microscopically. Additionally, DNA analyses with the polymerase chain reaction (PCR) were performed in two cases. Many nuclei of the stratum granulosa were diffusely immunolabelled for specific structural antigens of bovine papillomavirus (subgroup A), but nuclear inclusion bodies were not detected by retrospective examination of haematoxylin and eosin-stained sections of the affected skin. Aggregates of small numbers of viral particles (ranging from 37 to 43 nm in diameter) with a hexagonal structure were sparsely scattered throughout the nuclei of some of the superficial keratinocytes. PCR amplification targeted for the L1 gene of papillomavirus cloned from a case of CPEN yielded an expected fragment of 194-bp in the two CPEN cases examined but not in a case of canine oral papilloma.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/15737339/