Peer-reviewed veterinary case report
Understanding pilar neurocristic hamartoma in horses
By Tuthill, R J et al.·Published in Archives of dermatology·1982·View original on PubMed →
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Original publication title: Pilar neurocristic hamartoma: its relationship to blue nevus and equine melanotic disease.
- Species:
- horse
Plain-English summary
This study looks at a special type of skin growth called a pilar neurocristic hamartoma, which is made up of cells that come from the nervous system. It was found in a female horse and shares similarities with a condition known as equine melanotic disease, where there are pigmented spots on the skin. The researchers noted that the arrangement of the pigment cells in this growth is similar to what is seen in blue nevi, which are pigmented spots found in humans. They used special techniques to examine the structure of the cells and found that they resemble both nevus cells and Schwann cells, which are involved in nerve function. Overall, the study suggests that this unique skin growth has important connections to other known conditions.
Abstract
A unique pigmented lesion, judged to be a hamartoma of neural crest origin, occurring in a female patient, is compared with equine melanotic disease, The characteristic perifollicular arrangement of pigment-laden spindle cells is remarkably similar in both. Previously described patch- and plaque-like blue nevi in humans are also closely related. Light and ultrastructural features showed differentiation toward both nevus cells and Schwann cells, and it is proposed that the lesion be termed pilar neurocristic hamartoma.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/7103529/