Peer-reviewed veterinary case report
Placenta cell treatment for chronic mouth inflammation in cats
By M. Febre et al.·Published in Journal of Small Animal Practice·2022·View original on Semantic Scholar →
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Original publication title: Placenta-derived mesenchymal stromal cells as a treatment for refractory chronic gingivostomatitis in cats: eight cases (2018).
- Species:
- cat
Plain-English summary
Eight cats with severe gum disease known as chronic gingivostomatitis were treated with a single infusion of special cells derived from placenta. After the treatment, all cats showed significant improvement in their condition, as noted by both veterinary assessments and owner feedback. The treatment was found to be safe, and the cats experienced better health and behavior following the infusion. This new approach could be a promising option for cats suffering from this painful dental issue.
People also search for: cat gingivostomatitis treatment · cat gum disease symptoms · placenta-derived cells for cats
Abstract
OBJECTIVES The aim of this case series was to collect preliminary data on safety and efficacy of treating cats suffering from refractory feline chronic gingivostomatitis with a single intravenous therapy of cryopreserved placenta-derived mesenchymal stromal cells. MATERIALS AND METHODS We planned the prospective inclusion of cats suffering from refractory chronic gingivostomatitis in three veterinary clinics. All cats received a single infusion of 10×106 cryopreserved cells. Follow-up evaluations were done at day 15 and at 2-, 3- and 6-months following infusion. Clinical disease severity was evaluated by dental specialists using a published stomatitis disease activity index scoring system coupled with an owners' assessment questionnaire. RESULTS All eight cats attended all follow up visits. Cryopreserved ready-to-use placenta-derived cells administered systemically were safe and resulted in notable clinical improvement in all cats as reported by stomatitis disease activity index scoring and owner's survey. CLINICAL SIGNIFICANCE Infusion of cryopreserved freshly thawed placenta-derived mesenchymal stromal cells appears to promote clinical and consequently behavioural benefits in cats with refractory chronic gingivostomatitis after having undergone full-mouth or premolar-molar tooth extraction. Future randomised studies are required to confirm safety and efficacy of this treatment.
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Search related cases →Original publication on Semantic Scholar: https://www.semanticscholar.org/paper/36573276