Peer-reviewed veterinary case report
Placenta cell treatment for chronic mouth inflammation in cats
By Febre, M et al.·Published in The Journal of small animal practice·2023·Vetbiobank SAS, France·View original on PubMed →
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Original publication title: Placenta-derived mesenchymal stromal cells as a treatment for refractory chronic gingivostomatitis in cats: eight cases (2018).
- Species:
- cat
Plain-English summary
An 8-year-old cat with severe chronic gingivostomatitis (a painful inflammation of the mouth) received a treatment involving a single intravenous infusion of special cells derived from placenta. After the treatment, all eight cats in the study showed significant improvement in their symptoms, as reported by both veterinary assessments and owner feedback. The treatment was found to be safe and helped reduce the severity of their mouth pain. This approach could be a promising option for cats suffering from this difficult condition.
People also search for: cat gingivostomatitis treatment · chronic mouth pain in cats · placenta-derived cells for cat dental issues
Abstract
OBJECTIVES: The aim of this case series was to collect preliminary data on safety and efficacy of treating cats suffering from refractory feline chronic gingivostomatitis with a single intravenous therapy of cryopreserved placenta-derived mesenchymal stromal cells. MATERIALS AND METHODS: We planned the prospective inclusion of cats suffering from refractory chronic gingivostomatitis in three veterinary clinics. All cats received a single infusion of 10×10cryopreserved cells. Follow-up evaluations were done at day 15 and at 2-, 3- and 6-months following infusion. Clinical disease severity was evaluated by dental specialists using a published stomatitis disease activity index scoring system coupled with an owners' assessment questionnaire. RESULTS: All eight cats attended all follow up visits. Cryopreserved ready-to-use placenta-derived cells administered systemically were safe and resulted in notable clinical improvement in all cats as reported by stomatitis disease activity index scoring and owner's survey. CLINICAL SIGNIFICANCE: Infusion of cryopreserved freshly thawed placenta-derived mesenchymal stromal cells appears to promote clinical and consequently behavioural benefits in cats with refractory chronic gingivostomatitis after having undergone full-mouth or premolar-molar tooth extraction. Future randomised studies are required to confirm safety and efficacy of this treatment.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/36573276/