Peer-reviewed veterinary case report
Low vitamin E levels in dogs with chronic kidney disease stages
By Lippi, Ilaria et al.·Published in Veterinary research communications·2017·Department of Veterinary Science, Italy·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Plasma alpha-tochopherol determined by HPLC in dogs at different stages of chronic kidney disease: a retrospective study.
- Species:
- dog
Plain-English summary
A group of dogs with chronic kidney disease (CKD) showed lower levels of vitamin E (alpha-tocopherol) in their blood compared to healthy dogs. The study looked at dogs at different stages of CKD and found that those in the early (IRIS stage 1) and late (IRIS stage 4) stages had the most significant deficiencies. This suggests that dogs with CKD might benefit from a special kidney diet and antioxidants to help improve their vitamin E levels. If your dog has kidney disease, discussing dietary changes and supplements with your vet could be helpful.
People also search for: dog kidney disease treatment · vitamin E for dogs with kidney disease · renal diet for dogs with CKD
Abstract
The aim of the present study was to investigate retrospectively the plasma concentration of alpha-tocopherol in dogs with naturally acquired chronic kidney disease (CKD), at different stages of severity. Forty dogs (CKD group) with different stages of CKD (IRIS 1 n=12, IRIS 2 n=8, IRIS 3 n=11, IRIS 4 n=9) and 20 clinically healthy dogs were considered. Plasma alpha-tocopherol was assessed in both groups through high performance liquid chromatography (HPLC). Dogs of CKD group showed significantly lower (p=0.0002) levels of plasma alpha-tocopherol compared with clinically healthy dogs. A significant difference (p<0.04) in the number of patients with plasma alpha-tocopherol > or ≤ 21.5 ppm was found in CKD patients at different stages of severity. No significant correlation between plasma levels of alpha-tocopherol and plasma creatinine was found. In the present study, dogs affected by spontaneous CKD showed significantly lower plasma concentrations of alpha-tocopherol compared with clinically healthy dogs. Plasma alpha-tocopherol deficiency seems to be more severe in IRIS stage 1 and 4, compared with IRIS stage 2 and 3. The finding of marked alpha-tocopherol deficiency in patients in IRIS stage 1 should encourage further studies on the early use of prescription renal diet and antioxidant in this group of patients.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/28488081/