Peer-reviewed veterinary case report
Inflammatory markers in dogs with sepsis at ICU admission
By DeClue, A E et al.·Published in Journal of veterinary internal medicine·2012·Department of Veterinary Medicine and Surgery, United States·View original on PubMed →
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Original publication title: Plasma inflammatory mediator concentrations at ICU admission in dogs with naturally developing sepsis.
- Species:
- dog
Plain-English summary
A group of dogs with sepsis, a serious infection that can cause severe illness, were admitted to the intensive care unit for treatment. Researchers compared their blood levels of certain inflammatory substances to those of healthy dogs and dogs with a similar condition called noninfectious systemic inflammatory response syndrome (NSIRS). While dogs with sepsis and NSIRS had higher levels of some inflammatory markers, these tests did not reliably predict which dogs would recover. Ultimately, some dogs with sepsis did survive, but the specific blood tests used were not helpful in determining their outcomes.
People also search for: dog sepsis symptoms · dog ICU treatment · inflammatory markers in dogs
Abstract
BACKGROUND: Identifying biomarkers to aide in the diagnosis and prognostication of sepsis in dogs would be valuable to veterinarians. OBJECTIVE: To compare plasma inflammatory mediator concentrations among dogs with sepsis, noninfectious systemic inflammatory response syndrome (NSIRS), and healthy dogs. ANIMALS: Dogs with sepsis (n = 22), NSIRS (n = 23), and healthy dogs (n = 13) presenting to the intensive care unit (ICU) at a veterinary teaching hospital. METHODS: Prospective observational study. Clinical parameters were recorded for each dog and plasma tumor necrosis factor (TNF) bioactivity and concentrations of interleukin (IL)-6, CXC chemokine ligand (CXCL)-8 and IL-10 were determined at ICU presentation. RESULTS: Dogs with sepsis and NSIRS were significantly more likely to have measurable TNF activity (sepsis 20/22; NSIRS 19/20; healthy 0/13) and IL-6 concentration (sepsis 12/22; NSIRS 15/23; healthy 2/13), than healthy dogs. Healthy dogs (9/13) were significantly more likely to have measurable plasma IL-10 concentrations than dogs with sepsis (4/19), but not NSIRS (7/20). None of the inflammatory mediators evaluated had optimal sensitivity or specificity for the diagnosis of sepsis. Twelve of 22 dogs with sepsis and 15/23 dogs with NSIRS survived to discharge; none of the measured biomarkers correlated with survival to discharge. CONCLUSIONS AND CLINICAL IMPORTANCE: Sepsis and NSIRS are associated with increased production of the proinflammatory cytokines TNF and IL-6. In addition, sepsis is associated with decreased production of the anti-inflammatory cytokine IL-10. Despite this, plasma TNF, IL-6, CXCL-8, and IL-10 measured at ICU presentation do not appear to be valuable biomarkers to differentiate sepsis from NSIRS, or predict hospital outcome.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/22404367/