Peer-reviewed veterinary case report
High plasma MMP-9 levels found in cats with lymphoma
By Tamamoto, T et al.·Published in Veterinary and comparative oncology·2017·Department of Veterinary Internal Medicine, Japan·View original on PubMed →
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Original publication title: Plasma matrix metalloproteinase-9 activity in cats with lymphoma.
- Species:
- cat
Plain-English summary
A group of cats with lymphoma had their blood tested for a specific protein called MMP-9 before and after treatment. The tests showed that cats with lymphoma had higher levels of MMP-9 compared to healthy cats, indicating that this protein could be linked to the disease. After four weeks of treatment, the MMP-9 levels in the cats with lymphoma decreased, suggesting that monitoring this protein might help vets track how well the treatment is working. This could be a useful tool for managing feline lymphoma in the future.
People also search for: cat lymphoma treatment · high MMP-9 in cats · monitoring lymphoma in cats
Abstract
In this study, plasma MMP-9 activity was evaluated in cats with lymphoma. Plasma samples were obtained from 26 cats with lymphoma before treatment. From 13 of the included 26 cats, plasma samples were obtained 4 weeks after the initiation of treatment. Plasma samples were also obtained from 10 healthy cats as a control. Plasma MMP-9 activity was examined by gelatin zymography and semi-quantitative value (arbitrary unit; a.u.) for each sample was calculated. Relatively high levels of MMP-9 were observed in cats with lymphoma compared with those in healthy control cats. MMP-9 quantification through zymography showed significantly higher activity in cats with lymphoma (median, 0.63 a.u.; range, 0.23-3.24 a.u.) than in healthy controls (0.22 a.u.; 0.12-0.46 a.u.; P < 0.01). MMP-9 activities were significantly different before (0.73 a.u.; 0.30-3.24 a.u.) and after treatment (0.50 a.u.; 0.14-1.32 a.u.; P = 0.017). Measuring plasma MMP-9 activity in cats with lymphoma may become an appropriate monitoring tool for feline lymphoma.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/24899544/