Peer-reviewed veterinary case report
Platelet problems in dogs with Leishmania and Ehrlichia infections
By Cortese, L et al.·Published in Journal of veterinary medicine. A, Physiology, pathology, clinical medicine·2006·Dipartimento di Scienze Cliniche Veterinarie, Italy·View original on PubMed →
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Original publication title: Platelet aggregation and haemostatic response in dogs naturally co-infected by Leishmania infantum and Ehrlichia canis.
- Species:
- dog
Plain-English summary
A group of dogs infected with both Leishmania (which causes leishmaniasis) and Ehrlichia (which causes ehrlichiosis) showed problems with their blood platelets, which are important for clotting. These dogs had lower platelet function compared to those infected with just one of the diseases or none at all. The study found that these co-infected dogs had longer blood clotting times and changes in certain blood protein levels. Understanding how these infections affect blood clotting can help veterinarians manage the health of affected dogs better.
People also search for: dog bleeding problems · Leishmania Ehrlichia co-infection treatment · dog blood clotting issues
Abstract
Haemostatic alterations in dogs naturally infected by ehrlichiosis and/or leishmaniasis were studied. Platelet count, ADP and collagen-induced platelet aggregation, prothrombin time, activated partial thromboplastin time (APTT) and plasma fibrinogen concentration were measured. An evident reduction of platelet aggregation response was shown for Leishmania-Ehrlichia co-infected dogs where platelet aggregation was lower in comparison with control and leishmaniotic dogs (ADP and collagen, P < or = 0.01) and ehrlichiotic dogs (ADP 10 and 7.5 microm, P < or = 0.05). Moreover, a significant increase in APTT as well as a reduction of the albumin/globulin rate (A/G) for leishmaniotic and co-infected dogs versus control and ehrlichiotic dogs was detected. The hypothesis of a synergism between leishmaniosis and ehrlichiosis in altering platelet function by different pathways is discussed.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/17105577/