Peer-reviewed veterinary case report
Dog with muscle inflammation, eye inflammation, and skin color loss
By Lee, Mary Ann et al.·Published in BMC veterinary research·2023·School of Veterinary Medicine, United States·View original on PubMed →
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Original publication title: Polyautoimmunity manifest as inflammatory myopathy, uveitis, and progressive cutaneous depigmentation in a mixed breed dog: a case report.
- Species:
- dog
Plain-English summary
A 1-year-old male mixed breed dog was brought to the vet because he was losing color in his fur and skin, had eye inflammation, and was having trouble chewing due to muscle weakness. The vet found that the dog had multiple autoimmune issues affecting his skin, eyes, and muscles. Tests showed severe changes in his muscle and skin tissues. Treatment details weren't specified, but the diagnosis highlighted the need for careful management of these complex conditions.
People also search for: dog skin color loss · dog eye inflammation treatment · autoimmune disease in dogs
Abstract
BACKGROUND: Polyautoimmunity is the expression of more than one autoimmune disease in a single patient. This report documents polyautoimmunity in a mixed breed dog with concurrent uveitis, cutaneous depigmentation, and inflammatory myopathy. CASE PRESENTATION: A 1-year-old male neutered mixed breed dog was presented for progressive generalized leukotrichia and leukoderma, bilateral panuveitis, and masticatory muscle atrophy. The latter progressed to myositis of lingual, pharyngeal, and masticatory muscles confirmed by biopsy. Temporalis muscle was completely replaced by adipose and fibrous tissue, and necrotic myofibers with extensive infiltration of mononuclear cells indicated active myositis of lingual muscle. Skin biopsies showed severe melanin clumping in epidermis, hair follicles, and hair shafts, and perifollicular pigmentary incontinence. Uveitis, depigmentation, and myositis affecting the masticatory, pharyngeal, and tongue muscles were diagnosed based on clinical, histological, and laboratory findings. CONCLUSIONS: To the authors' knowledge, this is the first report of concurrent uveitis, progressive cutaneous depigmentation, and inflammatory myopathy in a dog.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/37817164/