Peer-reviewed veterinary case report
Blindness and brain abnormalities in Standard Poodles
By Jurney, C et al.·Published in Journal of veterinary internal medicine·2009·Neurology Department, United States·View original on PubMed →
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Original publication title: Polymicrogyria in standard poodles.
- Species:
- dog
Plain-English summary
Five Standard Poodles were brought in with symptoms of cortical blindness and various neurological issues, including changes in gait and behavior. Imaging tests showed that their brains had multiple small, disorganized folds, which is a sign of a condition called polymicrogyria. One dog also experienced seizures, as confirmed by an electroencephalogram (EEG). While all dogs had issues with the occipital lobe of the brain, some had additional areas affected. The study highlights a wider age range for this condition and suggests that hydrocephalus (fluid buildup in the brain) is less common than previously thought.
People also search for: Standard Poodle neurological problems · dog seizures treatment · cortical blindness in dogs · polymicrogyria in dogs · dog behavior changes neurological issues
Abstract
BACKGROUND: Polymicrogyria is a disorder of cerebrocortical migration resulting in increased numbers of small, disorganized gyri. This disorder occurs in Standard Poodles and in cattle. OBJECTIVES: To describe the clinical, electroencephalographic, imaging, and histopathologic features in poodles with polymicrogyria. ANIMALS: Five Standard Poodles with histologically confirmed polymicrogyria. METHODS: Retrospective case series. Cases were obtained by personal communication with 1 of 2 authors (TJVW, DPO). RESULTS: All dogs had cortical blindness and other neurologic abnormalities including gait and behavioral changes. Magnetic resonance imaging of 3 dogs showed multiple disorganized gyri, which were especially apparent on T2-weighted dorsal plane images. Electroencephalogram (EEG) of 1 dog revealed epileptiform discharges, including both spike and spike and wave discharges with voltage maximum potentials over the parietal/occipital region. The EEG supported that the repetitive behavior displayed by the dog was a complex partial motor seizure. One dog had concurrent hydrocephalus. All dogs had occipital lobe involvement and 2 dogs had involvement of other lobes. CLINICAL IMPORTANCE: The cases presented here demonstrate a larger age range (7 weeks to 5 years) and a decreased frequency of associated hydrocephalus when compared with the previous report.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/19566852/