Peer-reviewed veterinary case report
Slc11a1 gene differences linked to canine leishmaniasis risk
By Sanchez-Robert, E et al.·Published in The Journal of heredity·2005·Servei Veterinari de Genè, Spain·View original on PubMed →
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Original publication title: Polymorphism of Slc11a1 (Nramp1) gene and canine leishmaniasis in a case-control study.
- Species:
- dog
Plain-English summary
A study found that certain genetic variations in the Slc11a1 gene may influence whether dogs develop leishmaniasis, a disease spread by sandflies. In a group of 97 dogs, researchers discovered that boxers with a specific genetic marker (TAG-8-141) were more likely to be affected by the disease, while those with another marker (TAG-9-145) were often healthy. This suggests that genetics can play a significant role in a dog's risk of getting leishmaniasis, especially in certain breeds like boxers. Understanding these genetic factors could help in managing and preventing the disease in susceptible dogs.
People also search for: dog leishmaniasis symptoms · boxer dog genetic diseases · how to prevent leishmaniasis in dogs
Abstract
The prevalence of canine leishmaniasis infection in an endemic area such as the Mediterranean basin (67%) is higher than the prevalence of the disease (10%), suggesting a role of host genetics related to the outcome of the disease. Because Slc11a1 gene affects susceptibility and clinical outcome of autoimmune and infectious diseases, we analyzed five polymorphisms of the Slc11a1 gene in a case-control study with 97 dogs: three new single nucleotide polymorphisms and a G-stretch in the promoter and a microsatellite in intron 1. Haplotype frequency distributions showed significant differences between case and control populations (P = .01), most likely owing to the single nucleotide polymorphisms in the promoter region that were associated to case dogs. The most frequent haplotypes included TAG-8-141, which was present in all the breeds, in both case and control animals; and TAG-9-145, which was overrepresented in the control population and mostly found in boxer dogs. Within the boxer breed, 81% of the healthy dogs were homozygous TAG-9-145, whereas TAG-8-141 was significantly associated to case boxers (P = .02). The special genotype distribution for the Slc11a1 polymorphism associated with the prevalence of the illness in the boxer breed emphasizes the potential importance that breed genetic background has in canine leishmaniasis susceptibility.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/16251521/