Peer-reviewed veterinary case report
How polyphenols and CBD affect dog skin allergy genes
By Massimini, Marcella et al.·Published in Frontiers in veterinary science·2021·R&D Division, Italy·View original on PubMed →
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Original publication title: Polyphenols and Cannabidiol Modulate Transcriptional Regulation of Th1/Th2 Inflammatory Genes Related to Canine Atopic Dermatitis.
- Species:
- dog
Plain-English summary
A dog with atopic dermatitis (a common skin allergy) was treated with a special mixture of natural ingredients, including flavonoids and cannabinoids, to help reduce itching and inflammation. The treatment worked by changing how certain genes related to the dog's immune response were expressed, leading to less inflammation in the skin. This suggests that these natural compounds could be beneficial for dogs suffering from skin allergies. More research is needed, but the initial results are promising for improving skin health in dogs.
People also search for: dog itching treatment · natural remedies for dog skin allergies · atopic dermatitis in dogs treatment
Abstract
Canine atopic dermatitis (AD) is a multifactorial allergic disease associated with immune and abnormal skin barrier dysfunction and it is one of the primary causes of pruritus. Using a novelmodel of AD, here we tried to revert the alteration of transcriptional regulation of AD canine key genes testing a nutraceutical mixture containing flavonoids, stilbene, and cannabinoids, which are already well-known for their applications within dermatology diseases. The nutraceutical mixture induced in inflamed cells a significant downregulation (< 0.05) of the gene expression of, andin keratinocytes and of, andin monocytes. Consistent with the observed alterations of, andmessenger RNA (mRNA) levels, a significant increase (< 0.05) of DNA methylation at specific CpG sites on the gene regulatory regions was found. These results lay the foundation for the use of these natural bioactives in veterinary medicine and provide a model for deeper understanding of their mechanisms of action, with potential translation to human research.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/33763461/