Peer-reviewed veterinary case report
Post-meal fat in dogs causes oxidative stress in blood tests
By Bonatto, Natália Camila Minucci et al.·Published in Research in veterinary science·2021·Department of Preventive Veterinary Medicine, Brazil·View original on PubMed →
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Original publication title: Postprandial lipemia causes oxidative stress in dogs.
- Species:
- dog
Plain-English summary
A group of healthy dogs had blood samples taken after eating to see how their bodies reacted to high fat levels in their blood, known as postprandial lipemia. The study found that this condition increased certain markers of oxidative stress, which can indicate how well the body is handling stress from fats. While some markers increased significantly, others remained unchanged. The findings suggest that after a fatty meal, it might be best to avoid testing for oxidative stress in dogs, as the results could be misleading.
People also search for: dog high fat meal effects · postprandial lipemia in dogs · oxidative stress in dogs after eating
Abstract
Oxidative stress (OS) has been strongly associated with postprandial lipemia (PPL) in humans, and still requires further investigation in dogs. However, since lipemia interferes with spectrophotometric determinations such as those used to assess OS, the present study investigated the effect of PPL on OS parameters of healthy dogs. Twenty dogs had lipemic postprandial samples compared to the average of two non-lipemic moments. Subsequently, PPL was simulated in vitro using a commercial lipid emulsion and twelve pools of non-lipemic serum of these dogs were used to simulate the minimum, median and maximum concentrations of triglycerides obtained during the lipemic state. Serum OS parameters were assessed using the antioxidants uric acid, albumin and total bilirubin; total antioxidant capacity (TAC); total oxidant capacity (TOC); and lipid peroxidation. In vivo PPL caused an increase in albumin, TAC-CUPRAC, TAC-FRAP, uric acid (p < 0.0001), TOC (p = 0.0012) and total bilirubin (p = 0.0245); reduction of TAC-ABTS (p = 0.0008); and did not alter the lipid peroxidation (p = 0.8983). In vitro, levels of albumin increased at the three lipemic concentrations (p < 0.0001), uric acid increased in the median and maximum levels (p < 0.0001), and total bilirubin concentration increased only at the maximum lipemic level (p = 0.0012). All lipemic levels tested increased TAC-ABTS (p = 0.0011) and TAC-FRAP (p < 0.0001). TAC-CUPRAC (p = 0.5002), TOC (p = 0.5938) and lipid peroxidation (p = 0.4235) were not affected by in vitro lipemia. In conclusion, both the in vivo postprandial state and in vitro simulated lipemia affect oxidative stress markers in dogs depending on the oxidative stress marker, and thus the postprandial state and/or lipemic samples should be avoided.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/33725655/