Peer-reviewed veterinary case report
Does high blood fat cause oxidative stress in obese dogs
By Pereira, Yuri Lima et al.·Published in Research in veterinary science·2025·Department of Preventive Veterinary Medicine, Brazil·View original on PubMed →
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Original publication title: Does hypertriglyceridemia induce increased oxidative stress in obese dogs?
- Species:
- dog
Plain-English summary
A study found that obese dogs can experience increased oxidative stress, which may lead to health problems. In this research, 58 adult and senior dogs were divided into groups based on their weight: overweight, obese, and ideal body condition. The results showed that obese dogs had higher levels of certain markers indicating oxidative stress and inflammation, particularly those with high triglyceride levels. This suggests that while obesity is a concern, having high triglycerides is linked to more significant oxidative damage in these dogs.
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Abstract
Obesity is considered the most common nutritional disorder in pets. It triggers a low-grade inflammatory process that can lead to increased oxidative stress and contribute to various diseases. The purpose of this study was to evaluate the systemic levels of oxidative stress biomarkers in dogs with overweight, obesity and ideal body condition score (BCS). Fifty-eight adult and senior dogs were selected and divided into three groups: overweight (n = 20), obese (n = 20), and ideal BCS (n = 18). Oxidative stress biomarkers were measured using lipid peroxidation products, by ferrous oxidation-xylenol orange (FOX), advanced oxidative protein products (AOPP), and total reactive antioxidant potential (TRAP), with C-reactive protein (CRP) concentration used as an inflammatory biomarker. Protein oxidation was observed in overweight and obese dogs, as evidenced by elevated AOPP levels (p = 0.004) and their ratio to antioxidant levels (AOPP/TRAP) through the prooxidant-antioxidant index (PAI) (p = 0.015) in obese dogs. In obese dogs with hypertriglyceridemia, lipid oxidation (p = 0.018) was observed in addition to protein oxidation (p < 0.001). Furthermore, a positive correlation was observed between the triglyceride levels and AOPP (r = 0.716, p < 0.001) and PAI (r = 0.749, p < 0.001) concentrations. Finally, we concluded that obesity alone may not be sufficient to induce increased oxidative stress and that hypertriglyceridemia is correlated with protein and lipid oxidation in obese dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/40441076/