Peer-reviewed veterinary case report
How aging changes cholesterol and triglycerides in dogs
By Kawasumi, Koh et al.·Published in BMC veterinary research·2014·Department of Veterinary Science, Japan·View original on PubMed →
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Original publication title: Age effects on plasma cholesterol and triglyceride profiles and metabolite concentrations in dogs.
- Species:
- dog
Plain-English summary
A study found that older dogs, particularly those aged 8 to 13 years, tend to have higher levels of certain fats in their blood compared to younger dogs aged 0 to 7 years. Specifically, older dogs had significantly more triglycerides in one specific fraction and lower levels of a protein called adiponectin, which is linked to fat metabolism. This suggests that as dogs age, their ability to manage fats in their bodies changes, which could lead to health issues like obesity or diabetes. Regular check-ups and monitoring of blood lipid levels in older dogs may help manage these risks.
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Abstract
BACKGROUND: In dogs, occurrence of lipid metabolism disorders such as obesity and diabetes mellitus has increased markedly in recent years. Hyperlipidemia has been regarded as a common characteristic for obese animals and hyperlipidemic condition may be associated with inflammation, oxidative stress and lipid composition changes. In this study, we investigated the changes in plasma cholesterol and triglyceride (TG) profiles and metabolite concentrations in 24 dogs (young group: 0-7 years old, n = 12, aged group: 8-13 years old, n = 12). RESULTS: Plasma adiponectin (ADN) concentrations were significantly lower in aged dogs than those in young dogs (mean ± SD, 17.2 ± 10.0 μg mL-1 vs 29.3 ± 12.5 μg mL-1, respectively; P <0.05). Although there were no significant differences statistically, aged dogs showed significantly higher plasma alpha1- acid glycoprotein (alpah1-AG) levels compared to those in young dogs. Plasma cholesterol lipoprotein and TG lipoprotein were divided into four fractions by biphasic agarose gel electrophoresis technique. The levels of the third TG-lipoprotein fraction from the positive pole (TG Fraction 3) were significantly higher in aged dogs than in young dogs (mean ± SD, 143.0 ± 109.3 mg dL-1 vs 55.2 ± 31.3 mg dL-1, respectively; P <0.05). On the correlation coefficient analysis by Peason's method, moderate positive correlations were seen between the age and TG (r = 0.446, P = 0.029), TG Fraction 3 (r = 0.516, P = 0.010), malondialdehyde (r = 0.146, P = 0.043), alpha-1 AG (r = 0.448, P = 0.028) levels, respectively. Moderate negative correlations were seen the age and total cholesterol (TC) Fraction 2 (r = -0.446, P = 0.029), glucose (r = -0.637, P = 0.001), ADN (r = -0.408, P = 0.048), respectively. CONCLUSIONS: Present data suggest biochemical characteristics of lipid metabolism disorder may be affected by aging in dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/24597741/