Peer-reviewed veterinary case report
Weight loss effects on blood markers in obese female dogs
By Cavalcante, Carolina Zaghi et al.·Published in Canadian journal of veterinary research = Revue canadienne de recherche veterinaire·2023·Medicina Veteriná·View original on PubMed →
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Original publication title: Weight loss modifies lipid peroxidation and symmetric dimethylarginine levels in obese dogs.
- Species:
- dog
Plain-English summary
A group of obese female dogs was put on an 8-week weight-loss program to see how it affected their health. Before starting, the dogs had high levels of certain harmful substances in their bodies, which indicated oxidative stress and potential health issues. After the program, the dogs showed significant reductions in these harmful substances, suggesting that losing weight helped improve their overall health. This study highlights the importance of weight management in reducing health risks for obese dogs.
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Abstract
In obese dogs, oxidative stress is associated with inflammatory processes and systemic endocrine imbalances. Monitoring oxidative status is an early and valuable means of obesity control as it is a marker of weight loss, which leads to a reduction in oxidative status or injury potential. The objective of this study was to investgate the changes in the concentrations of thiobarbituric acid reactive substances (TBARS) and symmetric dimethylarginine (SDMA) in obese female dogs subjected to an 8-week weight-loss program. We included obese female dogs without comorbidities and with body condition scores (BCS) of 8 and 9 out of 9. In addition to TBARS and SDMA assessments, laboratory tests of blood and urine (blood count; levels of serum biochemistry; albumin, alanine aminotransferase, alkaline phosphatase, creatinine, urea, triglycerides, cholesterol, and glucose; urinalysis; and albuminuria), systolic blood pressure, and hormone concentrations (insulin, cortisol, and free thyroxine) were carried out before and after the weight-loss program. All the obese dogs presented high TBARS levels. After the program, the dogs showed significant reductions in TBARS (= 0.005) and SDMA (= 0.0013). In conclusion, obese female dogs were prone to lipid peroxidation and the TBARS and SDMA levels decreased after the 8-week weight-loss program.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/36606041/