Peer-reviewed veterinary case report
Insulin resistance and hormone changes in dogs gaining weight
By Gayet, C et al.·Published in Journal of animal physiology and animal nutrition·2004·USC INRA de Nutrition et Endocrinologie, France·View original on PubMed →
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Original publication title: Insulin resistance and changes in plasma concentration of TNFalpha, IGF1, and NEFA in dogs during weight gain and obesity.
- Species:
- dog
Plain-English summary
A group of dogs was overfed for seven months to study how obesity affects their health. During this time, the dogs gained an average of 43% of their body weight and showed a significant decrease in insulin sensitivity, which can lead to diabetes. Blood tests revealed increased levels of certain hormones and fatty acids associated with obesity. These findings suggest that the hormonal changes in overweight dogs could contribute to insulin resistance, a common issue in pets that are overweight.
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Abstract
Obesity-induced insulin resistance (IR) is a common problem in humans as well as domestic dogs. It is well-known that this syndrome is associated with many modifications but it is still unclear if the changes are alterations or adaptations. The purpose of this study was to develop obesity-induced IR in dogs, through a long-term overfeeding period, and to explore hormonal and metabolic disturbances associated with the development of this syndrome. Dogs were overfed for 7 months. Body weight increased by 43 +/- 5%, and insulin sensitivity decreased by 44 +/- 5%. Plasma insulin-like growth factor 1 (IGF1), tumour necrosis factor alpha (TNFalpha), and non-esterified fatty acids (NEFA) concentrations progressively increased during the overfeeding period (IGF1: 111 +/- 13 to 266 +/- 32 ng/ml, p < 0.001; TNFalpha: 5 +/- 5 to 134 +/- 41 pg/ml; NEFA: 0.974 +/- 0.094 to 1.590 +/- 0.127 mmol/l, p < 0.05). These metabolic and hormonal impairments are associated with IR, in obese dogs, and could explain, at least in part, the outbreak of this syndrome.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/15059241/