Peer-reviewed veterinary case report
POT1 gene mutations linked to cell growth in dog lymphoma
By Fanelli, Antonella et al.·Published in Frontiers in Veterinary Science·2022·View original on Crossref →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: POT1 mutations are frequent and associated with Ki-67 index in canine diffuse large B-cell lymphoma
- Species:
- dog
Plain-English summary
A study found that about one-third of dogs with diffuse large B-cell lymphoma (DLBCL), a serious type of cancer, had mutations in a gene called POT1. While these mutations were common, they didn't seem to predict how well the dog would do overall. However, dogs with these mutations had a higher Ki-67 index, which indicates more rapid cell growth. This suggests that the mutations might help the cancer cells grow faster. If your dog has been diagnosed with DLBCL, it's important to discuss treatment options with your veterinarian.
People also search for: dog lymphoma treatment · POT1 mutations in dogs · diffuse large B-cell lymphoma prognosis
Abstract
Diffuse large B-cell lymphoma (DLBCL) represents one of the most frequent and deadliest neoplasia in dogs worldwide and is characterized by a remarkable degree of clinical heterogeneity, with poor chances to anticipate the outcome. Even if in the last years some recurrently mutated genes have been identified, the genetic origin of canine DLBCL (cDLBCL) is not yet completely understood. The aim of the present study was to assess the prevalence of POT1 mutations in cDLBCL and to elucidate the role of such gene in the pathogenesis of this tumor. Mutations in POT1 were retrieved in 34% of cases, in line with previous reports, but no significant associations with any clinico-pathological variable were identified. Likewise, POT1 mutations are not predictive of worse prognosis. Interestingly, Ki-67 index was significantly higher in dogs harboring POT1 mutations compared to wild-type ones. These results suggest that POT1 mutations may exert their pathogenic role in cDLBCL by promoting cellular proliferation.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on Crossref: https://doi.org/10.3389/fvets.2022.968807