Peer-reviewed veterinary case report
New protein test using rLc36 improves dog visceral leishmaniasis
By Nogueira, Camila Tita et al.·Published in Memorias do Instituto Oswaldo Cruz·2018·Universidade Estadual Paulista·View original on PubMed →
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Original publication title: Potential application of rLc36 protein for diagnosis of canine visceral leishmaniasis.
- Species:
- dog
Plain-English summary
A study found that a new protein called rLc36 could help diagnose visceral leishmaniasis (VL) in dogs, which is a serious disease that can be fatal if not treated. This protein was tested in an immunoassay and showed an 85% sensitivity (correctly identifying infected dogs) and 71% specificity (correctly identifying healthy dogs). This means it could be a useful tool for vets to more accurately diagnose this disease in dogs, helping to ensure they receive the right treatment sooner.
People also search for: dog leishmaniasis symptoms · how to diagnose leishmaniasis in dogs · treatment for canine visceral leishmaniasis
Abstract
Visceral leishmaniasis (VL) is fatal if left untreated. Infected dogs are important reservoirs of the disease, and thus specific identification of infected animals is very important. Several diagnostic tests have been developed for canine VL (CVL); however, these tests show varied specificity and sensitivity. The present study describes the recombinant protein rLc36, expressed by Leishmania infantum, as potential antigen for more sensitive and specific diagnosis of CVL based on an immunoenzymatic assay. The concentration of 1.0 μg/mL of rLc36 enabled differentiation of positive and negative sera and showed a sensitivity of 85% and specificity of 71% (with 95% confidence), with an accuracy of 76%.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/29412359/