Peer-reviewed veterinary case report
Radiation therapy allowing higher doses for dog nasal cancer
By Vaudaux, Catherine et al.·Published in Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·2007·Vetsuisse-Faculty University of Zü·View original on PubMed →
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Original publication title: Potential for intensity-modulated radiation therapy to permit dose escalation for canine nasal cancer.
- Species:
- dog
Plain-English summary
A group of nine dogs with nasal tumors received a new type of radiation therapy called intensity-modulated radiation therapy (IMRT) to treat their cancer. This method allowed for a higher dose of radiation to be focused on the tumors while reducing the amount of radiation that reached the brain and eyes, which helped lower the risk of side effects. The results showed that IMRT not only delivered a more precise dose to the tumor but also significantly reduced the chances of complications in the surrounding healthy tissues. All dogs treated with IMRT had a better chance of protecting their eyes and experiencing fewer side effects.
People also search for: dog nasal cancer treatment · IMRT for dogs · radiation therapy side effects in dogs · dog tumor treatment options
Abstract
We evaluated the impact of inverse planned intensity-modulated radiation therapy (IMRT) on the dose-volume histograms (DVHs) and on the normal tissue complication probabilities (NTCPs) of brain and eyes in dogs with nasal tumors. Nine dogs with large, caudally located nasal tumors were planned using conventional techniques and inverse planned IMRT for a total prescribed dose of 52.5 Gy in 3.5 Gy fractions. The equivalent uniform dose for brain and eyes was calculated to estimate the normal tissue complication probability (NTCP) of these organs. The NTCP values as well as the DVHs were used to compare the treatment plans. The dose distribution in IMRT plans was more conformal than in conventional plans. The average dose delivered to one-third of the brain was 10 Gy lower with the IMRT plan compared with conventional planning. The mean partial brain volume receiving 43.6 Gy or more was reduced by 25.6% with IMRT. As a consequence, the NTCPs were also significantly lower in the IMRT plans. The mean NTCP of brain was two times lower and at least one eye could be saved in all patients planed with IMRT. Another possibility with IMRT is dose escalation in the target to improve tumor control while keeping the NTCPs at the same level as for conventional planning. Veterinary
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/17899986/