Peer-reviewed veterinary case report
Miniature horses with prekallikrein deficiency - what to know
By Turrentine, M A et al.·Published in American journal of veterinary research·1986·View original on PubMed →
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Original publication title: Prekallikrein deficiency in a family of miniature horses.
- Species:
- horse
Plain-English summary
Two sibling miniature horses, a male and a female, were found to have a blood clotting issue when they had a normal prothrombin time but a prolonged activated partial thromboplastin time (APTT), which means their blood took longer to clot. Tests showed they were deficient in a specific clotting factor called prekallikrein. Interestingly, when their blood was mixed with normal horse plasma, their clotting times improved. It appears that other family members may also carry this deficiency, but the horses themselves are being monitored for any related health issues.
People also search for: miniature horse blood clotting issues · prekallikrein deficiency in horses · horse prolonged APTT treatment
Abstract
Two sibling miniature horses, a male and a female, had a normal 1-stage prothrombin time and a prolonged activated-partial thromboplastin time (APTT). The addition of as little as 5% of a normal equine plasma pool to the plasma samples of both horses shortened their prolonged APTT to within normal limits. Coagulation factor analysis revealed deficiencies in factor XII (12 and 13 U/dl, control population 77 to 128 U/dl), when determined with a feline factor XII-deficient plasma substrate, but normal concentrations (119 and 96 U/dl) when a human factor XII-deficient plasma substrate was used. Deficiencies of another factor, prekallikrein, were detected with a human prekallikrein-deficient plasma substrate (16 and 6 U/dl, control population 70 to 173 U/dl). Other intrinsic coagulation factors were present in normal concentrations. The APTT was measured with plasma from the 2 horses after various incubation periods (1 to 15 minutes) with a contact activator before the addition of Ca ions. With incubation times of greater than or equal to 10 minutes, the APTT of both horses were essentially the same as that of the normal equine plasma pool. Several family members of the 2 prekallikrein-deficient miniature horses appeared to be heterozygous carriers of the prekallikrein deficiency.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/3641551/