Peer-reviewed veterinary case report
Serum clusterin levels may help detect lymphoma in dogs
By McNaught, Katie A et al.·Published in Veterinary and comparative oncology·2020·Small Animal Hospital, United Kingdom·View original on PubMed →
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Original publication title: Preliminary assessment of serum clusterin as a potential biomarker for canine lymphoma.
- Species:
- dog
Plain-English summary
A group of dogs with multicentric lymphoma (a type of cancer) had their blood tested for a protein called clusterin to see if it could help diagnose the disease. The tests showed that dogs with lymphoma had lower levels of clusterin compared to healthy dogs. However, once the dogs received treatment and went into remission, their clusterin levels were similar to those before treatment, making it unclear if this protein can be used as a reliable marker for the disease. More research is needed to determine if clusterin levels can predict outcomes for dogs with lymphoma.
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Abstract
Clusterin (CLU), also known as apolipoprotein J, is a widely expressed, heterodimeric, glycoprotein, important in tumourigenesis, apoptosis and immunoregulation. In humans, CLU expression has been associated with anaplastic large cell and Hodgkin's lymphoma. In this study, serum CLU levels in dogs with multicentric lymphoma (MLSA) were compared with healthy control dogs, using both western blot and enzyme-linked immunosorbent assay (ELISA). Western blot confirmed the presence of CLU in dog sera at the predicted molecular weight and the relative levels detected correlated with the levels detected by ELISA. CLU level analysis by ELISA found treatment naïve dogs with MLSA had a significantly (P < .001) lower serum CLU level compared with healthy controls. However, there was no significant difference between MLSA dogs prior to treatment and in complete remission. The wide variation in serum CLU levels may limit its potential as a single candidate biomarker for MLSA, although any prognostic predictive value of serum CLU concentrations has yet to be assessed.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/31654603/