Peer-reviewed veterinary case report
How kidney tests predict chronic kidney disease in dogs
By Cole, L P et al.·Published in The Journal of small animal practice·2026·Department of Clinical Science and Services, United Kingdom·View original on PubMed →
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Original publication title: Preliminary study investigating the role of estimated glomerular filtration rate, proteinuria and hypertension to inform on chronic kidney disease after acute kidney injury.
- Species:
- dog
Plain-English summary
A group of dogs with acute kidney injury were monitored over a year to see how their kidney function changed. Initially, 15 dogs were hospitalized, and while some improved, 10 still showed signs of kidney issues three months later. By the end of the study, most dogs were classified with early stages of chronic kidney disease, but only a few had persistent severe kidney problems. The findings suggest that even if a dog appears to recover, further testing can reveal ongoing kidney dysfunction.
People also search for: dog kidney disease symptoms · acute kidney injury in dogs · chronic kidney disease treatment for dogs
Abstract
OBJECTIVES: To assess chronic kidney disease in dogs after azotaemic acute kidney injury utilising serum creatinine, symmetric dimethylarginine and estimated glomerular filtration rate. MATERIALS AND METHODS: Client-owned dogs hospitalised for azotaemic acute kidney injury (T0) were evaluated at discharge (T1), 3 months (T2) and 12 (T3) months with serum creatinine and symmetric dimethylarginine measured. In non-azotaemic dogs (serum creatinine <145 μmol/L) at T1 and T2, glomerular filtration rate was estimated by iohexol clearance. Acute kidney injury grade and chronic kidney disease stage were determined according to International Renal Interest Society guidelines. Non-azotaemic dogs were considered to have kidney dysfunction if glomerular filtration rate was reduced ≥20% below the mean of the body weight category. RESULTS: Fifteen dogs with azotaemic acute kidney injury were recruited. At T0 peak, acute kidney injury grade was III (n = 4), IV (n = 8) and V (n = 3). At T1, 10/15 dogs remained azotaemic. At T2, 3/15 dogs remained azotaemic; this persisted in 2/3 dogs at T3. One dog was euthanised prior to T3 due to progression of azotaemia (stage 4). Based on glomerular filtration rate assessment, 4/12 and 5/12 non-azotaemic dogs had evidence of kidney dysfunction at T2 and T3, respectively. Ten out of 15 dogs were classified as International Renal Interest Society chronic kidney disease stage 1 and 4/15 dogs were stage 2 and 1/15 dog that did not survive to T3 was stage 4. CLINICAL SIGNIFICANCE: Persistent azotaemia occurs infrequently in dogs surviving beyond 3 months after acute kidney injury. Estimated glomerular filtration rate may identify continued kidney dysfunction in non-azotaemic dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/41466455/