Preparation of mesh covalent organic framework Tppa-2-based adsorption enhanced magnetic molecularly imprinted composite for selective extraction of tetracycline residues from animal-derived foods.

Abstract

In this study, for the first time, core-shell tetracycline hydrochloride-molecularly imprinted polymers (MIPs) were prepared by precipitation polymerization using a magnetic covalent organic framework (Fe₃O₄@Tppa-2) synthesized by room-temperature ultrasonic method as a substrate. Introducing Fe₃O₄@Tppa-2 into the molecular imprinting system can be used for efficient shortens the time for the adsorption equilibrium of MIPs due to its unique pore structure. The maximum adsorption capacity of MIPs was 87.50 mg/g, and the adsorption equilibrium reached in 14 min. The MIPs were used as magnetic solid-phase extraction sorbents in combination with high performance liquid chromatography for the determination of tetracycline in pork, chicken and chicken liver, and the detection limit reached 0.01 ng/mL. In addition, the adsorption advantages of MIPs suggest that it is a promising adsorbent for the recovery of antibiotics and has potential applications in the detection and enrichment of TC in food.