Peer-reviewed veterinary case report
White matter changes in a dog with corpus callosum hypoplasia
By Wang-Leandro, Adriano et al.·Published in Frontiers in veterinary science·2018·Clinic for Diagnostic Imaging·View original on PubMed →
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Original publication title: Presence of Probst Bundles Indicate White Matter Remodeling in a Dog With Corpus Callosum Hypoplasia and Dysplasia.
- Species:
- dog
Plain-English summary
A 4-year-old Staffordshire mix was diagnosed with abnormalities in the brain's corpus callosum, which can lead to seizures and other neurological issues. Advanced imaging showed that this dog's brain had unusual structures similar to those seen in humans with similar conditions. These changes might indicate that the dog's brain was trying to adapt and compensate for the missing connections. Despite the serious nature of the condition, the dog had a fair prognosis, suggesting that some dogs can still lead relatively normal lives with proper care.
People also search for: dog seizures treatment · Staffordshire mix brain problems · corpus callosum abnormalities in dogs
Abstract
Corpus callosum abnormalities (CCA) rarely occur in dogs and are related to hypo/adypsic hypernatremia and seizures. Hypoplasia and dysplasia of the corpus callosum (CC) with concomitant lobar holoprosencephaly is the most common variant. It is currently uncertain using conventional MRI if canine CCA reflects the failure of commissural fibers to develop or the failure of the commissural fibers to cross hemispheres. Diffusion tensor imaging was performed in a 4-year-old Staffordshire mix breed dog with CCA and an age-matched healthy Beagle. In comparison to the control dog, CC tractography of the affected dog depicted only axonal tracts corresponding to the temporal CC fibers. The cingulum bundles appeared supernumerary with unorganized architecture, extending into the ipsilateral cerebral cortex, and therefore strongly suggested homology to Probst bundles reported in humans with CCA. The presence of Probst bundles in canine CCA could represent compensatory neuroplasticity-mediated networking and may contribute the fair prognosis reported in affected dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/30406119/