Peer-reviewed veterinary case report
Dog develops kidney problems and nephrotic syndrome after masitinib
By Devine, Lauren & Polzin, David J·Published in The Canadian veterinary journal = La revue veterinaire canadienne·2016·North Carolina State Veterinary Hospital - Internal Medicine, United States·View original on PubMed →
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Original publication title: Presumed masitinib-induced nephrotic syndrome and azotemia in a dog.
- Species:
- dog
Plain-English summary
A dog developed kidney problems, specifically nephrotic syndrome and acute kidney injury, after being treated with a medication called masitinib for mast cell tumors. The symptoms included signs of kidney distress, which can manifest as increased thirst, urination, or lethargy. The report emphasizes the importance of regular check-ups, including blood tests and urine analysis, to monitor kidney function while on this medication. Adjusting treatment based on these tests can help manage the dog's health effectively.
People also search for: dog kidney problems after masitinib · signs of kidney disease in dogs · mast cell tumor treatment side effects
Abstract
Masitinib mesylate is a tyrosine-kinase inhibitor approved for the treatment of nonresectable or recurrent, Grade 2 or 3 mast cell tumors in dogs. This report describes nephrotic syndrome and acute kidney injury attributed to masitinib and illustrates the need for regular monitoring of serum creatinine concentration, urinalysis, and urine protein:creatinine ratio during its use.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/27429464/