Peer-reviewed veterinary case report
Dog with muscle lymphoma causing breathing trouble and weight loss
By Thuilliez, Céline et al.·Published in Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·2008·Department of Pathology, France·View original on PubMed →
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Original publication title: Presumed primary muscular lymphoma in a dog.
- Species:
- dog
Plain-English summary
An 8-year-old male Newfoundland was brought to the vet because he had a large mass in his neck, was having trouble breathing, and had lost his appetite over the past month. Tests showed that he had a type of cancer called anaplastic large cell lymphoma affecting his muscles. Unfortunately, despite receiving chemotherapy, his condition worsened, and he was euthanized a few weeks later. A thorough examination after his passing confirmed that the cancer had spread to multiple muscle groups in his body.
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Abstract
A case of presumed primary muscular lymphoma in an 8-year-old, intact, male Newfoundland dog is reported. The dog was presented for evaluation of an infiltrating ventral cervical mass, respiratory distress, and anorexia of 1-month duration. Fine-needle aspiration of the mass revealed anaplastic large cell lymphoma. Despite chemotherapy, health status declined and the animal was euthanized a few weeks later. At necropsy, the mass infiltrated the cervical muscles and extended ventrally to the left forelimb and cranially to the tongue and laryngeal musculature. Other muscles were infiltrated by the same neoplasm (diaphragm and intercostal, abdominal, and gluteal muscles) indicating a probable multicentric origin. Histological examination confirmed the diagnosis of anaplastic large cell lymphoma, which showed a strong muscular tropism. Immunohistochemical staining revealed neoplastic cell reactivity for cluster of differentiation 3 (CD3) and Ki-67 antigens (70% and 90%, respectively). The neoplastic cells were negative for CD79a. The presumed histological diagnosis in this dog was primary muscular anaplastic large T-cell lymphoma.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/18987239/