Peer-reviewed veterinary case report
Dog with suspected blood vessel clot disease treated successfully
By Laudhittirut, Tanarut et al.·Published in The Canadian veterinary journal = La revue veterinaire canadienne·2025·Department of Small Animal Clinical Sciences, Canada·View original on PubMed →
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Original publication title: Presumed successful steroid therapy for suspected thrombotic microangiopathy in a dog.
- Species:
- dog
Plain-English summary
A 2-year-old male Pembroke Welsh corgi was brought to the vet after suddenly starting to vomit and not wanting to eat. Despite initial treatments with fluids and medications, his condition worsened, leading to severe dark urine and jaundice. He was diagnosed with a rare condition called thrombotic microangiopathy, which caused anemia, low platelet counts, and kidney injury. The dog received supportive care and a short course of steroids, which helped him recover fully without any relapses over the next year.
People also search for: dog vomiting and not eating · Pembroke Welsh corgi kidney problems · treatment for dog anemia and jaundice
Abstract
A 2-year-old castrated male Pembroke Welsh corgi dog was presented to the referring veterinarian because of acute onset of vomiting and hyporexia. Despite conservative treatment with intravenous fluids, antiemetics, antibiotics, and antioxidants, the dog rapidly deteriorated, with development of severe pigmenturia and icterus over 24 to 48 h, respectively, prompting referral. A thrombotic microangiopathy (TMA) characterized by nonimmune-mediated hemolytic anemia, thrombocytopenia, and acute kidney injury (AKI), suspected to be from hemolytic uremic syndrome not associated with known prodromal diarrhea, was diagnosed. This is a rarely described disorder in dogs and, unlike those in most previous reports, this dog survived with supportive care for AKI and a short tapering course of glucocorticoids for refractory thrombocytopenia. Steroids have been reported for managing certain TMA syndromes in humans but not in animals. The dog in this case made a full recovery, with no reported relapse over 1 y. Key clinical message: Thrombotic microangiopathy is characterized by nonimmune-mediated hemolytic anemia, thrombocytopenia, and AKI. Corticosteroids may be beneficial for treating canine TMA, based on successful recovery in this rare case of non-diarrheal hemolytic uremic syndrome.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/41142981/