Peer-reviewed veterinary case report
Miniature Dachshunds with immune anemia and hemophagocytic syndrome
By Akiyoshi, Makoto et al.·Published in The Journal of veterinary medical science·2021·Azabu University, Japan·View original on PubMed →
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Original publication title: Presumptive hemophagocytic syndrome associated with immune-mediated anemia in two Miniature Dachshunds.
- Species:
- dog
Plain-English summary
Two Miniature Dachshunds were brought to the vet with severe anemia caused by their immune systems attacking their own red blood cells. Despite treatment with medications to suppress their immune response, their condition worsened, leading to complications like an enlarged spleen and low platelet counts. After further tests, both dogs were diagnosed with a serious condition called hemophagocytic syndrome (HPS) related to their anemia. Sadly, both dogs passed away shortly after the diagnosis. This case highlights the importance of considering HPS in dogs with severe anemia that doesn’t respond to treatment.
People also search for: Miniature Dachshund anemia treatment · immune-mediated hemolytic anemia in dogs · hemophagocytic syndrome in dogs
Abstract
This report describes the cases of two Miniature Dachshunds who were suspected to have immune-mediated hemolytic anemia (IMHA) and were treated with immunosuppressive therapy. However, progression of anemia, increases in C-reactive protein (CRP) and total-bilirubin (T-Bil) levels, splenomegaly, transition to nonregenerative anemia, and thrombocytopenia occurred after the treatment. Splenectomy and bone-marrow aspirations were performed subsequently. Both dogs were diagnosed with hemophagocytic syndrome (HPS) associated with IMHA. Unfortunately, they died 9 and 6 days later. These findings indicate that some cases of refractory IMHA have the pathogenicity of HPS. HPS should be included as a differential diagnosis of refractory IMHA concurrent with thrombocytopenia. Continuously elevated CRP and T-Bil levels may be helpful indicators in the detection of HPS associated with IMHA.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/33692231/