Peer-reviewed veterinary case report
Antinuclear antibodies and rheumatoid factor in dogs
By Tsouloufi, Theodora K et al.·Published in Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·2022·and Companion Animal Clinic·View original on PubMed →
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Original publication title: Prevalence of antinuclear antibodies and rheumatoid factor titers in dogs with arthritis secondary to leishmaniosis ().
- Species:
- dog
Plain-English summary
A group of dogs with arthritis caused by leishmaniosis (a disease spread by sandflies) were tested for certain antibodies in their blood. Out of 23 dogs, none showed positive results for antinuclear antibodies, and only 3 tested positive for rheumatoid factor. This suggests that these specific antibodies are not commonly present in dogs suffering from arthritis related to leishmaniosis. The findings indicate that pet owners shouldn't expect to see these antibodies in dogs with this type of arthritis.
People also search for: dog arthritis leishmaniosis treatment · leishmaniasis in dogs symptoms · rheumatoid factor in dogs
Abstract
Dogs with infectious arthritis may occasionally exhibit positive serum antinuclear antibody (ANA) and rheumatoid factor (RF) titers; however, relevant data are sparse for arthritis secondary to canine leishmaniosis (CanL) caused by. We determined the prevalence of positive serum ANA and RF titers in dogs with arthritis secondary to CanL. Blood samples from adult, client-owned dogs with purulent arthritis secondary to CanL, without any comorbidities, were collected for diagnostic purposes. Serum ANA titers were measured by immunoperoxidase test and RF titers by the Rose-Waaler latex test. Twelve of 23 dogs enrolled prospectively in our study had clinical arthritis, and 11 of 23 had subclinical arthritis. Based on LeishVet clinical staging, 7 dogs had clinical stage II disease, 11 had clinical stage III disease, and 5 had stage IV. None of the 23 dogs was seropositive for ANA; 3 of 23 were positive for RF. ANA and/or RF seropositivity, in dogs with CanL-associated arthritis, appears to be weak, if present at all. Based on our results, positive serum ANA and RF titers should not be expected in dogs with arthritis secondary to CanL.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/35655443/