Peer-reviewed veterinary case report
Rectal mass and bloody stool in young dogs caused by rare lymphoma
By Richardson, Michael A et al.·Published in Veterinary pathology·2019·1 Department of Pathobiology and Diagnostic Investigation, United States·View original on PubMed →
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Original publication title: Primary Colorectal Follicular Lymphoma in 3 Dogs.
- Species:
- dog
Plain-English summary
Three dogs, aged between 9 months and 2 years, were diagnosed with a rare type of cancer called primary colorectal follicular lymphoma, which affected their intestines. The dogs showed symptoms like straining to defecate, passing blood in their stool, and had a noticeable mass in the rectal area. For two of the dogs, the vet successfully removed a single mass, which seemed to cure them. Unfortunately, the third dog had multiple masses and later developed a more widespread form of lymphoma.
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Abstract
Primary colorectal follicular lymphomas are rare indolent lymphoid neoplasms in humans that have not been reported in dogs. We describe 3 cases of primary colorectal follicular lymphoma in dogs with histologic and immunohistochemical features similar to their human counterpart. Initial clinical signs in all dogs included tenesmus, hematochezia, and a palpable rectal mass. Two dogs were castrated males and 1 an intact female, between 9 months and 2 years of age, and of varied breeds. All 3 cases of colorectal follicular lymphoma were characterized by proliferation of follicular germinal centers with no polarity or mantle zone and were composed of centrocytes admixed with fewer centroblasts. By immunohistochemistry, lymphoid cells expressed CD20, BCL2, and BCL6 and lacked expression of CD3, CD5, and cyclin D1. Polymerase chain reaction for rearrangements of the immunoglobulin heavy chain confirmed a monoclonal population in all cases. In 2 of the 3 cases, a solitary nodular colorectal mass was excised and appeared curative; however, the third case had multiple colorectal masses and the animal developed multicentric lymphoma. This case series immunohistochemically characterizes and distinguishes colorectal follicular lymphoma from atypical lymphoid hyperplasia.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/30636538/