Peer-reviewed veterinary case report
Bleeding and clotting problems in dogs with acute kidney injury
By McBride, Duana et al.·Published in Journal of veterinary internal medicine·2019·Department of Clinical Science and Services, United Kingdom·View original on PubMed →
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Original publication title: Primary hemostatic function in dogs with acute kidney injury.
- Species:
- dog
Plain-English summary
A group of dogs with severe kidney injury showed signs of bleeding problems, which can happen when the kidneys aren't functioning well. In this study, researchers found that these dogs had lower levels of red blood cells and less effective platelet function compared to healthy dogs. This means that their blood wasn't clotting as well, which can lead to bleeding issues. The findings suggest that dogs with acute kidney injury may have a condition similar to a bleeding disorder called type II von Willebrand disease. It's important for pet owners to be aware of these risks and discuss any symptoms of bleeding with their veterinarian.
People also search for: dog kidney injury bleeding · dog blood clotting problems · signs of kidney disease in dogs
Abstract
BACKGROUND: Bleeding tendencies can occur with uremia. OBJECTIVES: To characterize primary hemostatic function in dogs with acute kidney injury (AKI). ANIMALS: Ten dogs with International Renal Interest Society AKI grade III or above and 10 healthy controls. METHODS: Prospective study comparing PCV, platelet count, platelet aggregometry (Multiplate), and von Willebrand factor antigen to collagen binding activity ratio (vWF:Ag:vWF:CBA) in 2 groups of dogs (AKI group versus controls). Buccal mucosal bleeding time was measured in the AKI group only. Data are presented as median [25th, 75th percentile] unless otherwise stated. Significance was set at P < .05. RESULTS: Mean PCV was significantly lower in the AKI (34.7%; ±SD, 8.8) than in the control (46.1%; ±SD, 3.6; P < .001) group. Platelet count was significantly higher in the AKI (350.5 × 10/μL [301, 516]) than in the control (241 × 10/μL [227, 251]; P = .01) group. Collagen-activated platelet aggregometry measured as area under the curve was significantly lower in the AKI (36.9 ± 17.7) than in the control (54.9 ± 11.2; P = .05) group. vWF:Ag:vWF:CBA was significantly higher in the AKI (2.2 [1.9, 2.6]) than in the control (1.1 [1.1, 1.2]; P = .01) group. There was a strong correlation between vWF:Ag:vWF:CBA and creatinine (r = 0.859; P < .001), but no other variables. CONCLUSIONS AND CLINICAL IMPORTANCE: Dogs with AKI had decreased collagen-activated platelet aggregation and appear to have a type II von Willebrand disease-like phenotype as indicated by the high vWF:Ag:vWF:CBA.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/31381195/