Peer-reviewed veterinary case report
Brain tumor from malignant histiocytosis in a miniature schnauzer dog
By Chandra, A M & Ginn, P E·Published in Journal of comparative pathology·1999·Department of Pathobiology, United States·View original on PubMed →
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Original publication title: Primary malignant histiocytosis of the brain in a dog.
- Species:
- dog
Plain-English summary
A 10-year-old miniature schnauzer was brought in with neurological symptoms, including seizures and changes in behavior. After tests, the vet found a tumor in the dog's brain made up of abnormal immune cells. This type of tumor, known as malignant histiocytosis, is rare and often affects certain breeds like Bernese mountain dogs. Unfortunately, the prognosis for this condition is generally poor, and treatment options are limited. The dog received supportive care, but the outcome was not favorable due to the aggressive nature of the tumor.
People also search for: dog brain tumor symptoms · miniature schnauzer seizures · malignant histiocytosis in dogs
Abstract
Malignant histiocytosis is a well-recognized canine tumour, occurring primarily in Bernese mountain dogs and characterized by disseminated histiocytic infiltration of multiple visceral organs. This report describes the light microscopical and ultrastructural features of a neoplasm composed of malignant histiocytes and confined to the brain. A poorly demarcated mass in the right parieto-occipital lobe of a miniature schnauzer was composed of loosely aggregated, pleomorphic cells with abundant eosinophilic cytoplasm, expanding the meninges. Many binucleated and multinucleated giant cells and mitotic figures were seen. Immunohistochemically, the tumour cells reacted intensely for lysozyme. Ultrastructurally, the neoplastic cells had features of histiocytic cells with abundant lysosomes. The findings in this case were strikingly similar to those of disseminated malignant histiocytosis described in other dog breeds.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/10373296/