Peer-reviewed veterinary case report
Primary nervous system lymphoma in cats - signs and diagnosis
By Rissi, Daniel R et al.·Published in Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·2022·Department of Pathology.·View original on PubMed →
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Original publication title: Primary nervous system lymphoma in cats.
- Species:
- cat
Plain-English summary
A 9-year-old cat was diagnosed with primary nervous system lymphoma after showing signs of ataxia, which is a lack of coordination. In this case, the cat had tumors in the brain and spinal cord that were causing these symptoms. The tumors were identified through tests that looked at the cells involved, revealing a mix of B-cell and T-cell lymphomas. Unfortunately, the study does not provide information on treatment outcomes for these cats, but knowing the type of lymphoma can help veterinarians determine the best course of action for affected pets.
People also search for: cat ataxia causes · cat brain tumor symptoms · lymphoma treatment for cats
Abstract
Here we characterize the neuroanatomic distribution, neuropathology, and immunophenotype of 10 cases of primary nervous system lymphoma in cats. Cases were retrospectively searched from 2 academic institutions. Selected cases were reviewed and subjected to immunohistochemistry (IHC) for CD3, CD20, and Pax5. The mean age of affected cats was 9.1 y, and no sex or breed predilection was observed. The most common clinical sign was ataxia (8 cases). Gross changes reported in 8 cases consisted of white-to-tan masses (7 cases) or swelling (1 case) within the neuroparenchyma (5 cases) or epidural spaces (3 cases). Histologically, intraparenchymal lymphomas occurred in the gray and white matter or perivascular spaces (7 cases); extraparenchymal lymphomas (6 cases) consisted of neoplastic cell infiltration of the perivascular spaces in the leptomeninges, choroid plexus, or epidural spaces. Nerve lymphomas were diffusely infiltrative. Tumors occurred in the brain (4 cases), spinal cord and nerves (3 cases), spinal cord (2 cases), and brain, spinal cord, and nerves (1 case). IHC was consistent with a B-cell lymphoma in 5 cases and with a T-cell lymphoma in 5 cases.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/35442117/