Peer-reviewed veterinary case report
Cat with rare uterine lymphoma causing discharge and vomiting
By Cuzzupè, Y et al.·Published in The Journal of small animal practice·2025·Polo Oncologico Veterinario, Italy·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Primary uterine large granular lymphocyte lymphoma in an ovariectomised cat.
- Species:
- cat
Plain-English summary
An 11-year-old spayed female domestic short-haired cat was brought to the vet with a 3-month history of vaginal discharge, lethargy, vomiting, and constipation. The vet found swelling and discharge around the vulva, and imaging revealed a large mass in the abdomen. After performing surgery to remove the uterus, tests confirmed that the cat had a rare type of lymphoma. Unfortunately, a month later, follow-up imaging showed signs of the cancer spreading. This case highlights a very uncommon type of cancer in cats, and it’s important for pet owners to be aware of unusual symptoms.
People also search for: cat vomiting and lethargy · cat vaginal discharge · cat cancer treatment options · lymphoma in cats · signs of cat abdominal mass
Abstract
Primary uterine lymphoma is an extremely rare disease. An 11-year-old spayed female domestic short-haired cat presented with a 3-month history of mucopurulent vaginal discharge, lethargy, acute vomiting and constipation. Physical examination revealed vulvar swelling, purulent discharge and a mass in the mid-caudal abdomen. A CT scan identified a large uterine mass, displacing the colon dorsally and the urethra ventrally. A hysterectomy was performed. Histology and immunohistochemistry confirmed a T-cell uterine transmural medium to large cell lymphoma. One-month post-surgery, an abdominal ultrasound showed thickening of the jejunal loops, enlarged lymph nodes and nodular peritoneal lesions at the surgical site. Cytology raised suspicion of large granular lymphocyte lymphoma, confirmed by anti-Granzyme B immunohistochemistry on the uterine tissue specimen. The final diagnosis was primary uterine large granular lymphocyte lymphoma, marking the first reported case in small animal oncology.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/39828966/