Peer-reviewed veterinary case report
Oral chemotherapy with procarbazine, prednisolone
By O'Connell, Kathleen et al.·Published in Veterinary and comparative oncology·2022·Department of Oncology, Australia·View original on PubMed →
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Original publication title: Procarbazine, prednisolone and cyclophosphamide oral combination chemotherapy protocol for canine lymphoma.
- Species:
- dog
Plain-English summary
A group of 50 dogs with multicentric lymphoma (a type of cancer) that had not responded to previous treatments were given a new oral chemotherapy combination of procarbazine, prednisolone, and cyclophosphamide. This treatment was well tolerated, with only one dog needing to stop due to low platelet levels, and a few others experiencing mild stomach issues. Overall, about 70% of the dogs showed improvement, with nearly half achieving complete remission. This oral chemotherapy approach offers a promising option for dogs with lymphoma who have limited treatment choices.
People also search for: dog lymphoma treatment · oral chemotherapy for dogs · canine cancer survival rates
Abstract
Orally administered daily chemotherapy offers a novel treatment approach for canine lymphoma in a population of dogs that have failed or not tolerated maximum tolerable dose chemotherapy. A multidrug oral chemotherapy protocol was designed and implemented for the treatment of 50 dogs with multicentric lymphoma with minimal side effects. The protocol consisted of oral procarbazine, prednisolone and cyclophosphamide (PPC) administered daily. Efficacy and toxicity were evaluated by clinical and laboratory evaluation. An overall response rate of 70% was achieved, with 24% and 46% of dogs having a partial and complete response, respectively, to treatment with the PPC protocol. Response to the PPC protocol (complete or partial) and age were the only factors identified as prognostic for time from initiation of the PPC chemotherapy until death. Overall, the protocol was very well tolerated with only one dog requiring protocol discontinuation due to grade 4 thrombocytopenia. Eight dogs recorded gastrointestinal toxicities, seven grade I and one grade II toxicity. These findings demonstrate that the administration of a continuous oral combination chemotherapy can provide comparable survival times in the rescue setting in dogs with multicentric lymphoma with minimal side effects.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/35338560/