Peer-reviewed veterinary case report
Anti-Leishmania antibody levels linked to symptoms in dogs
By de Freitas, José Cláudio Carneiro et al.·Published in Research in veterinary science·2012·Programa de Pó, Brazil·View original on PubMed →
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Original publication title: Profile of anti-Leishmania antibodies related to clinical picture in canine visceral leishmaniasis.
- Species:
- dog
Plain-English summary
A group of dogs with leishmaniasis, a serious disease caused by a parasite, were tested for specific antibodies to understand their condition better. The study found that dogs showing symptoms had higher levels of certain antibodies compared to healthy dogs. In particular, the presence of IgG2 antibodies was linked to the clinical signs of the disease. This information could help veterinarians monitor and manage dogs with leishmaniasis more effectively.
People also search for: dog leishmaniasis symptoms · canine leishmaniasis treatment · dog antibody test for leishmaniasis
Abstract
This research investigated the profile of anti-Leishmania antibodies in different clinical forms of canine visceral leishmaniasis (CVL). Naturally infected dogs were divided into two groups: subclinical dogs (SD, n=10) and clinical dogs (CD, n=68). Non-infected dogs (ND, n=7) comprised the negative control group. The humoral response was evaluated by the profile of total IgG, IgG1, IgG2, IgM, IgA and IgE, determined by ELISA. Infected animals showed increased levels of total IgG, IgA and IgE in addition to IgG1 and IgG2 in groups SD and CD, when compared with group ND. Furthermore, it was observed that IgG2 and IgM were correlated with symptomatology, while total IgG, IgG1 and IgA were negatively correlated and IgE showed no correlation. It follows that serum levels of IgG2 anti-Leishmania are correlated with typical clinical signs of disease. Furthermore the determination of specific anti-Leishmania antibodies could be an important tool in monitoring CVL clinical picture.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/22226072/