Peer-reviewed veterinary case report
Serum metabolite differences in dogs with lymphoma detected by GC-MS
By Tamai, Reo et al.·Published in The Journal of veterinary medical science·2014·Graduate School of Life and Environmental Sciences, Japan·View original on PubMed →
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Original publication title: Profiling of serum metabolites in canine lymphoma using gas chromatography mass spectrometry.
- Species:
- dog
Plain-English summary
A group of dogs with lymphoma, a common type of cancer, had their blood tested to find differences in certain substances compared to healthy dogs. Researchers discovered that 16 specific metabolites were significantly different between the two groups, with most being higher in the dogs with lymphoma. This suggests that analyzing these metabolites could help in diagnosing lymphoma and possibly in detecting when the cancer might return after treatment. While chemotherapy often leads to remission, this study points to a potential new method for monitoring the disease in dogs.
People also search for: dog lymphoma symptoms · canine cancer blood test · lymphoma treatment for dogs
Abstract
Canine lymphoma is a common cancer that has high rates of complete remission with combination chemotherapy. However, the duration of remission varies based on multiple factors, and there is a need to develop a method for early detection of recurrence. In this study, we compared the metabolites profiles in serum from 21 dogs with lymphoma and 13 healthy dogs using gas chromatography mass spectrometry (GC-MS). The lymphoma group was separated from the control group in an orthogonal projection to latent structure with discriminant analysis (OPLS-DA) plot using ions of m/z 100-600, indicating that the metabolites profiles in lymphoma cases differed from those in healthy dogs. The lymphoma group was also separated from the control group on OPLS-DA plot using 29 metabolites identified in all serum samples. Significant differences were found for 16 of these metabolites with higher levels in the lymphoma group for 15 of the metabolites and lower levels for inositol. An OPLS-DA plot showed separation of the lymphoma and healthy groups using these 16 metabolites only. These results indicate that metabolites profile with GC-MS may be a useful tool for detection of potential biomarker and diagnosis of canine lymphoma.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/25131950/